Preface:
When it comes to wrinkle removal, many people think of botox. However, those who have undergone botox injections often experience this: indeed, the wrinkles disappear, but the face looks unnatural. Injected around the eyes, the crow's feet vanish, but the smile loses its sweetness. Injected into the forehead, the lines smooth out, but the eyes seem smaller.
The root cause of the problem lies in the fact that botox can only relax muscles without addressing the fundamental reasons for wrinkle formation. As muscles relax, nearby facial features are also affected.
The reason we develop wrinkles is not only due to muscle movements causing creases, but more importantly, it's the internal structural collapse and sagging caused by aging. Additionally, if the skin is too dry, it can also lead to the formation of fine lines.
In fact, a well-formulated topical product is sufficient to combat wrinkles without the side effects associated with botox injections, fulfilling the dream of quick and natural beauty enhancement for many.
Next, let me introduce the formulation logic of UNILIPO POLYPEPTIDE SERUM, and you'll see this is not just a daydream.
formulation logic
15%ARGIRELINE® peptide solution C
INCI name: Acetyl Hexapeptide-8, sourced from Lipotec S.A.U.
This ingredient needs no elaborate introduction, right? It's the ultimate choice for combating dynamic wrinkles, highlighting rapid wrinkle reduction!
Muscle movement requires signal transmission, which involves the formation of the SNARE complex to stimulate the release of neurotransmitters. The neurotransmitter ACh binds to receptors on the muscles, resulting in muscle contraction and movement.
Botulinum toxin can cleave the SNAP-25 protein, preventing the assembly of the SNARE complex and thereby blocking the release of ACh. This effectively reduces the formation of expression lines rapidly.
The Acetyl Hexapeptide-8 in Argireline mimics SNAP-25, causing cells to produce ineffective SNARE complexes, thereby reducing the release of neurotransmitters.
The principle is that simple. Argireline is highly acclaimed because, like botulinum toxin, it delivers fast results!
With just a 2% concentration, significant reduction in wrinkles can be observed in just 7 days
Moreover, since the hexapeptide works through competitive inhibition, it doesn't completely halt neurotransmitter production, alleviating concerns about stiff facial expressions.
In older versions, Argireline was added at 10%, but in the new version, it's increased to 15% because our product focuses on rapid wrinkle reduction. Waiting 7 days seems too long – perhaps 5 days? 1 day? 12 hours?
From my own observations, I've seen noticeable differences within 2 hours.
However, whether it's botox or hexapeptides, they only temporarily conceal wrinkles. Truly eliminating wrinkles relies on the other ingredients I'm about to introduce.
5%Matrixyl® 3000
INCI name: Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, sourced from Sederma
While Argireline functions through biomimetic inhibition, Matrixyl® 3000 relies on signal transmission.
It contains signal peptides that send signals to fibroblast cells in the dermis, stimulating the synthesis of collagen types 1, 4, 7, 17, fibronectin, and hyaluronic acid. This increases the strength of the extracellular matrix and basal layer of the dermis, achieving lifting and wrinkle-reducing effects.
In simple terms, Matrixyl® 3000 plumps up the dermis to push wrinkles upwards.
The primary components of the dermis accumulate gradually, indicating a relatively lengthy process. Therefore, clinical trials of Matrixyl® 3000 were conducted over 56 days.
In human trials, the concentration of Matrixyl® 3000 was 4%, but our upgraded peptide essence contains 5%.
Generally, a product aimed at wrinkle reduction achieving both rapid and long-lasting results is considered excellent.
However, UNILIPO always strives to exceed expectations. Next, we delve deeper into the root causes of wrinkles.
Whether it's wrinkles, sagging, or pigmentation, the fundamental cause is aging. As cells age, their efficiency decreases.
Most products on the market aim to reduce creases by inhibiting neurotransmitters and stimulating cells to work harder. However, few consider that we can actually rejuvenate cells to their youthful state!
UNISOUL® Reborn was born out of this very idea.
5% UNISOUL® Reborn
INCI name: PTEROCARPUS MARSUPIUM BARK EXTRACT, UNILIPO patented ingredient
Invention patent application number: 202310564303.5
Invention creation name: Preparation method and application of a whitening and anti-aging supramolecular Pterostilbene microcapsule
Unisoul is a collective term for our independently developed patented ingredients, aimed at making these special ingredients the soul of our products. Among them, the key component in UNISOUL® Reborn is Pterostilbene.
Through our educational efforts and promotions, more and more informed users are recognizing Pterostilbene as a treasure trove of ingredients. In vitro experiments have shown that its inhibitory ability against tyrosinase is 91 times that of kojic acid, so we've incorporated it into our whitening essence.
However, few ingredient enthusiasts know that the primary role of Pterostilbene is actually anti-aging, and it's a key active ingredient in some well-known anti-aging supplements in the United States.
Pterostilbene has gained attention in longevity science because it participates in multiple anti-aging-related signaling pathways.
For example, it activates the longevity protein Sirt1, induces cellular autophagy, protects mitochondria, and is involved in methionine restriction, among others. Each of these aspects is currently a hot topic in the field of longevity research.
Longevity proteins participate in DNA repair, metabolism, antioxidant stress responses, and other crucial physiological processes. They have been found to be significantly associated with lifespan extension in some organisms and play roles in stress responses and energy sensing.
Cellular autophagy is a way for cells to clear and regenerate their own components, especially under conditions of environmental stress or nutrient deficiency. It involves the breakdown and recycling of damaged or surplus cellular components, crucial for cellular homeostasis, growth, and survival.
What I want to convey is that UNISOUL® Reborn is never just about whitening. Its purpose is to fundamentally address aging issues, allowing cells to be reborn and regain new life.
To maximize the effectiveness of Pterostilbene, we've employed supramolecular microencapsulation and supramolecular ionic liquid technologies to extract and nano-encapsulate it.
In vitro experiments have shown that the modified UNISOUL® Reborn has significantly improved solubility, stability, transdermal penetration, and efficacy compared to the original.
In a double-blind placebo-controlled clinical trial conducted by a third-party laboratory, subjects who used 5% UNISOUL® Reborn continuously for 14 days experienced a significant decrease of 48.07% in the number of crow's feet wrinkles! By day 28, the reduction rate reached an astonishing 55.78%! 100% of the participants reported a reduction in their fine lines, and overall user satisfaction reached 100%.
UNISOUL® Reborn, Matrixyl® 3000, and Argireline make breakthroughs at various levels from the inside to the outside in addressing wrinkles.
Now, let's dig deeper into what causes cellular aging.
That's right—it's photoaging!
3% UNISOUL® Renew
INCI name: Silybum Marianum Extract, etc., UNILIPO patented ingredient
Invention patent application number: 202310605230.X
Invention creation name: Preparation method and application of a supramolecular silymarin compound
The molecular mechanisms of photoaging mainly include:
DNA damage: UV radiation can directly cause DNA damage, such as the formation of thymine dimers.
Free radicals and oxidative stress: UV radiation can increase the generation of free radicals, further triggering oxidative stress. Oxidative stress can damage cellular structures such as lipids, proteins, and DNA.
Inflammatory response: UV radiation can activate various inflammatory pathways and induce the production of inflammatory factors. Prolonged or repeated inflammatory responses can disrupt skin structure and function, accelerating aging.
Changes in immune response: UV radiation can affect the local immune response of the skin, weakening the skin's immune defense capabilities.
The silymarin in Silybum Marianum Extract can effectively combat each of the above issues.
Silymarin can reduce UVB-induced DNA mutations by enhancing the DNA repair rate through the excision repair mechanism in epidermal cells. It also exhibits antioxidant properties, reducing oxidative stress.
Moreover, it decreases the expression of inflammatory factors, thereby reducing inflammatory responses. Additionally, it can reverse UVB-induced immune suppression by reducing the production of IL-10 and draining lymph nodes.
The key point here is that the quality of silymarin in Silybum Marianum Extract determines the degree of protection against photoaging.
We use supercritical extraction technology and supramolecular cosolvent to extract silymarin from milk thistle. This process successfully enriches the active ingredients and improves their stability in the formulation. Additionally, it significantly enhances penetration efficiency.
We have named this patented ingredient UNISOUL® Renew, indicating that with its help, the skin will be renewed and revitalized.
All the aforementioned ingredients possess both protective and corrective, short-term and long-term skincare effects, leaving no room for wrinkles.
The following ingredients are some additional bonuses:
Acetyl Tetrapeptide-5 and Caffeine
Peptide essence is very gentle and can be directly applied to the eyes as an eye serum. Acetyl Tetrapeptide-5 and caffeine can reduce eye puffiness, counteract water retention, and enhance skin elasticity and smoothness. They are highly suitable for individuals aiming to reduce eye bags and puffiness.
Ceramide Complex, Glyceryl Glucoside, and Panthenol
The are responsible for moisturizing, repairing the skin barrier, and promoting the expression of aquaporins to reduce fine lines caused by skin dryness.
Supramolecular Muscle Peptides
AGE Detection Method: Immunostaining, for example, proves that glycation is widespread in aging skin.
Glycation can lead to characteristic structural, morphological, and functional changes in the skin.
Supramolecular muscle peptides have an anti-glycation capacity that is 20-30 times higher than regular muscle peptides, reducing wrinkles and sagging caused by protein denaturation due to glycation.
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