UNISOUL® RNAiW

A 12-week clinical study showed that UNISOUL® RNAiW showed better melasma removal effect by inhibiting the expression of MITF compared with 10% MAP (magnesium ascorbyl phosphate, a whitening ingredient).

UNISOUL® RNAiW significantly inhibited the four most critical genes, MITF, TYR, TRP-1, and TRP-2, at both the mRNA transcription level and the protein expression level.

Left image: The silencing effect of siRNA on the transcription level of the MITF gene.

Right image: The silencing effect of siRNA on several key genes in the melanin synthesis pathway. The thicker and darker the band, the higher the expression level; the thinner and lighter the band, the lower the expression level, indicating the achieved effect.

Using 0.8% UNISOUL® RNAiW, the melanin content is 64.7% lower than that of kojic acid. And this is only 0.8% content, while our pterostilbene essence has a 5% concentration.

Statistical data show that using UNISOUL® RNAiW raw material for only 28 days can significantly reduce skin melanin (2.44%) and significantly improve skin brightness (1.53%).