Among the extensive collection of cutting-edge raw materials sent to me by the supplier Sytheon, I found a promising active ingredient. Let's dive in together to discover what this active ingredient is all about.
This active ingredient is: Synoxyl® AZ, INCI name: 【Acetyl Zingerone】.
First, let's take a look at the peer-reviewed professional papers they have published for this ingredient.
The information is extensive, let's go through it step by step.
Antioxidant:
Firstly,【Acetyl Zingerone】 is a versatile antioxidant expert.
We all know we need antioxidants, but what exactly are they fighting against? They're a group of highly oxidative substances, including singlet oxygen, superoxide anions, hydrogen peroxide, hydroxyl radicals, and peroxynitrite, among others. So far, no antioxidant has been able to tackle all oxidative species.
【Acetyl Zingerone】 contains a variety of functional groups, including phenolic groups that can donate hydrogen ions, methoxy groups that can physically quench singlet oxygen, and carbonyl groups that can scavenge peroxynitrite.
In addition, 【Acetyl Zingerone】 can selectively chelate free divalent iron, inhibit the Fenton reaction, thereby preventing the further production of the most damaging hydroxyl radicals in the skin.
According to Sytheon's comparative experiments, in various tests for the elimination of active oxygen species, 【Acetyl Zingerone 】outperformed completely, completely surpassing vitamin E and resveratrol.
The data is from Sytheon
Acetyl Zingerone can efficiently scavenge or eliminate singlet oxygen, hydrogen peroxide, hydroxyl radicals, and peroxynitrite, with efficiency ranging from 18 to 127 times that of vitamin E and 158 to 470 times that of resveratrol.
A special note: Due to its efficient chelation of iron ions, it's also a must-have ingredient for menopausal individuals, effectively preventing premature aging caused by excessive iron levels in the body.
In short, among the plethora of peroxides, apart from being unable to tackle superoxide anions, Acetyl Zingerone annihilates all others upon their appearance.
Protect DNA:
In addition to its potent antioxidant capabilities, it can also protect our DNA.
Research has found that with 【Acetyl Zingerone】 treatment, UV-induced dimers (a mutation of DNA) are significantly reduced. Even as a post-UV remedy, 【Acetyl Zingerone】 exhibits a significant anti-mutagenic effect.
During the day, it provides potent antioxidant protection for DNA, while at night, Acetyl Zingerone continues to reduce subsequent DNA mutations caused by daytime UV exposure.
In addition to antioxidation and DNA protection, Sytheon has conducted numerous other in vitro experiments, such as stability tests, gene expression profiling, and synergistic effects with other active ingredients, among others. But I won't delve into those details here.
Clinical Efficacy:
While the data from in vitro experiments is impressive, what are the actual effects when applied to the face? To investigate this, Sytheon conducted an 8-week randomized, double-blind, placebo-controlled trial.
Participants applied a cream containing or not containing Acetyl Zingerone daily, and measurements of the participants' skin were taken after the 4th and 8th weeks.
The data is from Sytheon
According to the data from the above chart, participants who used the cream containing Acetyl Zingerone showed significant improvements in the severity of wrinkles, overall wrinkle volume, skin pigmentation, and redness.
Not only is it effective, but it also exhibits high safety, as there were no reports of significant itching, burning, or stinging among the participants. Moreover, it didn't disrupt the microbial balance on the surface of the participants' skin.
With just this one ingredient, providing protection, brightening, and wrinkle reduction, supported by ample data, Acetyl Zingerone stands out purely based on its efficacy.
Currently, this ingredient has not been included in the cosmetic raw material catalog in China, so fans who want to use it in advance can only resort to products manufactured in the United States.
Furthermore, it's not easy to find products containing Acetyl Zingerone, as only forward-thinking brands like Revision, Isomers, Murad, and Unilipo are likely to incorporate it, But Revision, Isomers, Murad, the exact dosage is not always clearly stated.
The following are some products that currently contain Acetyl Zingerone:
